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A new scientific analysis links GlaxoSmithKline’s widely prescribed diabetes drug Avandia to greater risk of heart attack and possibly death.

The world’s top-selling oral diabetes treatment may raise a patient’s chance of having a heart attack and potentially increase the risk of death, researchers said.

The study, released by the New England Journal of Medicine, reflects data from 42 studies involving 15,560 patients who took the drug and 12,283 patients who were given other medications or a placebo. Patients getting Avandia were 43 percent more likely to have a heart attack. The study also suggested a trend toward higher death rates in the Avandia group.

The results cast into doubt the safety of a drug that generated sales of $3 billion last year, even as competing medications are eating into growth.
In mid-day trading, GSK shares were down $2.80 to $54.91.

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